Jose Mourinho is likely to make several changes for the visit of the Championship side, with the likes of Luke Shaw, Michael Carrick and Sergio Romero vying for a starting place in this third-round tie.
Marcos Rojo, Axel Tuanzebe and Paul Pogba all remain on the treatment table for the hosts.
This will be the third time the two sides will have played each other, with the Brewers famously holding the Red Devils to a 0-0 draw when they were a conference side in 2006.
Follow all of the action from Old Trafford as it happens right here.
Manchester United: Romero, Darmian, Lindelof, Smalling, Blind, Carrick, Herrera, Lingard, Mata, Martial, Rashford
Subs: Pereira, Jones, Shaw, Young, McTominay, Fellaini, Lukaku
Burton: Ripley, Allen, Turner, Lund, Dyer, Flanagan, Naylor, Varney, Palmer, Mason, Akpan
Subs: Campbell, Warnock, McFadzean, Murphy, Akins, Sordell, Scannell